KEGG   Oryctolagus cuniculus (rabbit): 100037716
Entry
100037716         CDS       T03373                                 
Symbol
ATP2A1
Name
(RefSeq) sarcoplasmic/endoplasmic reticulum calcium ATPase 1
  KO
K05853  P-type Ca2+ transporter type 2A [EC:7.2.2.10]
Organism
ocu  Oryctolagus cuniculus (rabbit)
Pathway
ocu04020  Calcium signaling pathway
ocu04022  cGMP-PKG signaling pathway
ocu04024  cAMP signaling pathway
ocu04148  Efferocytosis
ocu04260  Cardiac muscle contraction
ocu04261  Adrenergic signaling in cardiomyocytes
ocu04380  Osteoclast differentiation
ocu04919  Thyroid hormone signaling pathway
ocu04972  Pancreatic secretion
ocu05010  Alzheimer disease
ocu05017  Spinocerebellar ataxia
ocu05022  Pathways of neurodegeneration - multiple diseases
ocu05410  Hypertrophic cardiomyopathy
ocu05412  Arrhythmogenic right ventricular cardiomyopathy
ocu05414  Dilated cardiomyopathy
ocu05415  Diabetic cardiomyopathy
Brite
KEGG Orthology (KO) [BR:ocu00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04020 Calcium signaling pathway
    100037716 (ATP2A1)
   04024 cAMP signaling pathway
    100037716 (ATP2A1)
   04022 cGMP-PKG signaling pathway
    100037716 (ATP2A1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04148 Efferocytosis
    100037716 (ATP2A1)
 09150 Organismal Systems
  09152 Endocrine system
   04919 Thyroid hormone signaling pathway
    100037716 (ATP2A1)
  09153 Circulatory system
   04260 Cardiac muscle contraction
    100037716 (ATP2A1)
   04261 Adrenergic signaling in cardiomyocytes
    100037716 (ATP2A1)
  09154 Digestive system
   04972 Pancreatic secretion
    100037716 (ATP2A1)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    100037716 (ATP2A1)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    100037716 (ATP2A1)
   05017 Spinocerebellar ataxia
    100037716 (ATP2A1)
   05022 Pathways of neurodegeneration - multiple diseases
    100037716 (ATP2A1)
  09166 Cardiovascular disease
   05410 Hypertrophic cardiomyopathy
    100037716 (ATP2A1)
   05412 Arrhythmogenic right ventricular cardiomyopathy
    100037716 (ATP2A1)
   05414 Dilated cardiomyopathy
    100037716 (ATP2A1)
   05415 Diabetic cardiomyopathy
    100037716 (ATP2A1)
Enzymes [BR:ocu01000]
 7. Translocases
  7.2  Catalysing the translocation of inorganic cations
   7.2.2  Linked to the hydrolysis of a nucleoside triphosphate
    7.2.2.10  P-type Ca2+ transporter
     100037716 (ATP2A1)
SSDB
Motif
Pfam: E1-E2_ATPase Cation_ATPase_C Cation_ATPase Cation_ATPase_N Hydrolase Hydrolase_3 HAD
Other DBs
NCBI-GeneID: 100037716
NCBI-ProteinID: NP_001082787
Ensembl: ENSOCUG00000002688
UniProt: P04191
Structure
Position
6:18715353..18734172
AA seq 1001 aa
MEAAHSKSTEECLAYFGVSETTGLTPDQVKRHLEKYGHNELPAEEGKSLWELVIEQFEDL
LVRILLLAACISFVLAWFEEGEETITAFVEPFVILLILIANAIVGVWQERNAENAIEALK
EYEPEMGKVYRADRKSVQRIKARDIVPGDIVEVAVGDKVPADIRILSIKSTTLRVDQSIL
TGESVSVIKHTEPVPDPRAVNQDKKNMLFSGTNIAAGKALGIVATTGVSTEIGKIRDQMA
ATEQDKTPLQQKLDEFGEQLSKVISLICVAVWLINIGHFNDPVHGGSWIRGAIYYFKIAV
ALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQ
MSVCKMFIIDKVDGDFCSLNEFSITGSTYAPEGEVLKNDKPIRSGQFDGLVELATICALC
NDSSLDFNETKGVYEKVGEATETALTTLVEKMNVFNTEVRNLSKVERANACNSVIRQLMK
KEFTLEFSRDRKSMSVYCSPAKSSRAAVGNKMFVKGAPEGVIDRCNYVRVGTTRVPMTGP
VKEKILSVIKEWGTGRDTLRCLALATRDTPPKREEMVLDDSSRFMEYETDLTFVGVVGML
DPPRKEVMGSIQLCRDAGIRVIMITGDNKGTAIAICRRIGIFGENEEVADRAYTGREFDD
LPLAEQREACRRACCFARVEPSHKSKIVEYLQSYDEITAMTGDGVNDAPALKKAEIGIAM
GSGTAVAKTASEMVLADDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAA
LGLPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMDRPPRSPKEPLISGWLFFRYMAI
GGYVGAATVGAAAWWFMYAEDGPGVTYHQLTHFMQCTEDHPHFEGLDCEIFEAPEPMTMA
LSVLVTIEMCNALNSLSENQSLMRMPPWVNIWLLGSICLSMSLHFLILYVDPLPMIFKLK
ALDLTQWLMVLKISLPVIGLDEILKFIARNYLEDPEDERRK
NT seq 3006 nt   +upstreamnt  +downstreamnt
atggaggccgcgcactccaagagcacagaggaatgtctggcctattttggggtgagcgag
accacaggcctcaccccggaccaagtgaagcgacatctagagaaatacggccacaatgag
cttcctgctgaggaagggaaatccctgtgggagctggtgatagagcagtttgaagacctc
ctggtgcggattcttctgctggccgcctgcatctcctttgtgctggcctggtttgaagaa
ggggaagagaccatcactgccttcgttgagccctttgtcatcctcctgatcctcattgcc
aatgccatcgtgggagtttggcaggagcggaacgctgagaacgccatagaggcgctgaag
gaatatgagcccgagatggggaaggtgtaccgggctgaccgcaagtcagtgcaaaggatc
aaggctcgggacatcgtccccggggacatcgtggaggtggcggttggggacaaagtccct
gcagacatccgcatcctgtctatcaagtccaccaccctccgcgtggaccagtccatcctg
acaggcgagtctgtgtccgtcatcaagcacacggagccagtccctgacccgcgggctgtc
aaccaggacaagaagaacatgcttttctcgggtaccaacatcgcggccggcaaggccctg
ggcatcgtggccaccaccggcgtgagcaccgagatcgggaagatccgtgaccagatggcc
gccacggagcaggacaagacgccgctgcagcagaagctggatgagttcggggagcagctg
tccaaggtcatctccctcatctgcgtggccgtgtggcttatcaacatcggccacttcaac
gaccccgtccacgggggctcctggatccgcggtgccatctactacttcaagatcgccgtg
gccttggctgtggctgcgatcccagaaggtcttcccgctgtcatcactacctgcctggcc
ctgggcacccgccggatggcgaagaagaacgccatcgtgaggagcctgccctctgtggag
accctgggctgcacctctgtcatctgctctgacaagactggcaccctcaccaccaaccag
atgtctgtgtgcaagatgttcatcatcgacaaggtggacggagacttctgttcgctgaac
gagttctccatcaccggctccacctacgctccagagggggaggtcctgaagaatgataaa
cccatccggtcagggcagtttgatgggctggtggagctggccaccatttgtgccctgtgc
aatgattcctccttggacttcaatgagaccaaaggcgtctatgagaaggtgggtgaggcc
acggagacggcgctcaccaccctggtggagaagatgaatgtgttcaacacggaagttcgg
aacctctcgaaggtggagagagccaacgcctgcaactcggtgatccgccagctcatgaag
aaagagttcaccctggagttctcccgagacaggaagtccatgtctgtgtactgttctcca
gccaaatcttcccgcgctgctgtgggcaacaagatgtttgtcaagggcgcccccgagggg
gtcatcgaccgctgtaactacgtgcgagtcggcaccacccgggtgcccatgactgggccg
gtgaaggagaagatcctctccgtgatcaaggagtggggcaccggccgggacacgctgcgc
tgcctggccctggccacccgcgacacgccgcccaagcgagaggaaatggtgctggacgac
tcctcccggttcatggagtacgagacggacctgacgttcgtgggcgtcgtgggcatgctg
gacccgccccgcaaggaggtcatgggctccatccagctgtgccgggacgccgggatccgt
gtcatcatgatcaccggcgacaacaagggcacggccatcgccatctgccgccgcatcggc
atctttggggagaacgaggaggtggcagaccgcgcctacaccggccgcgagtttgacgac
ctgcccctggccgagcagcgggaagcctgccgccgcgcctgctgcttcgcgcgcgtggaa
ccctcccacaagtccaagatcgtggaatacctgcagtcctacgatgagatcacggccatg
acaggggatggcgtcaacgatgcccctgccctgaagaaggccgagatcggcatagctatg
ggatctggcaccgccgtggccaagacagcgtctgagatggtcctggcggacgacaacttc
tccaccatcgtggccgccgtggaggagggccgggccatctacaacaacatgaagcagttc
atccgctacctcatctcctccaacgtgggcgaggtggtctgcatcttcctgacggccgcc
ttggggctgcccgaggccctgatccccgtgcagctgctgtgggtgaacctggtgacggac
gggctcccggccacagccctgggcttcaacccaccagacctggacatcatggaccggccc
ccccggagtcccaaggagcccctgatcagtggctggctcttcttccgctacatggccatc
gggggctatgtgggtgcagccaccgtgggagccgctgcctggtggttcatgtatgcggag
gatgggccgggtgtcacctaccaccagctgacccacttcatgcagtgcaccgaggaccac
cctcactttgagggtctggactgtgagatctttgaggccccagagcccatgaccatggcc
ttgtctgtgctggtgaccatcgagatgtgcaatgctctcaacagcctgtccgagaaccag
tccttgatgcggatgccgccctgggtgaacatctggctgctgggctccatctgcctgtcc
atgtccctccacttcctcatcctctacgtcgaccccctgccgatgatcttcaagctcaag
gccctagacctcacccagtggctcatggtcctcaagatctcacttccagtcatcgggctg
gatgaaatactcaagttcattgctcggaactacctggaggatccagaagatgaaaggagg
aagtaa

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (16)   
   KEGG PATHWAY (16)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (18)   
   KEGG ORTHOLOGY (1)   
   RefGene (13)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (4)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (2)   
DNA sequence (14)   
   RefSeq(nuc) (2)   
   GenBank (6)   
   EMBL (6)   
3D Structure (76)   
   PDB (76)   
Protein domain (7)   
   Pfam (7)   
All databases (139)   

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